Trans-regulatory functions in the Abdominal-B gene of the bithorax complex.
نویسندگان
چکیده
We have investigated the functional organization of the Abdominal-B gene in the bithorax complex using the expression of the Ultrabithorax gene as an assay for Abdominal-B trans-regulatory functions. Using Polycomb mutants to relax the normal spatial control of Ultrabithorax expression, we have examined the effects of Abdominal-B mutations on the expression of Ultrabithorax protein products in parasegment 14. The results support the hypothesis that the Abdominal-B gene contains two trans-regulatory functions: the m element active in parasegments 10-13 and the r element acting exclusively in parasegment 14.
منابع مشابه
Genetic and molecular characterization of a novel iab-8 regulatory domain in the Abdominal-B gene of Drosophila melanogaster.
Homeotic (or Hox) genes are key determinants in specifying the anteroposterior axis of most animals. The temporal and spatial expression of these genes requires the presence of large and complex cis-regulatory regions. The Abdominal-B Hox gene of the bithorax complex of Drosophila is regulated by several infraabdominal domains, which determine Abdominal-B expression in abdominal segments A5 to ...
متن کاملA novel promoter-tethering element regulates enhancer-driven gene expression at the bithorax complex in the Drosophila embryo.
A key question in our understanding of the cis-regulation of gene expression during embryonic development has been the molecular mechanism that directs enhancers to specific promoters within a gene complex. Promoter competition and insulators are thought to play a role in regulating these interactions. In the bithorax complex of Drosophila, the IAB5 enhancer is located 55 kb 3' of the Abdominal...
متن کاملThe border between the ultrabithorax and abdominal-A regulatory domains in the Drosophila bithorax complex.
The bithorax complex in Drosophila melanogaster includes three homeobox-containing genes--Ultrabithorax (Ubx), abdominal--A (abd-A), and Abdominal-B (Abd-B)-which are required for the proper differentiation of the posterior 10 segments of the body. Each of these genes has multiple distinct regulatory regions; there is one for each segmental unit of the body plan where the genes are expressed. O...
متن کاملCharacterization of new regulatory elements within the Drosophila bithorax complex
The homeotic Abdominal-B (Abd-B) gene expression depends on a modular cis-regulatory region divided into discrete functional domains (iab) that control the expression of the gene in a particular segment of the fly. These domains contain regulatory elements implicated in both initiation and maintenance of homeotic gene expression and elements that separate the different domains. In this paper we...
متن کاملRegulation of the infraabdominal regions of the bithorax complex of Drosophila by gap genes.
The expression of the abdominal-A and Abdominal-B genes of the bithorax complex of Drosophila is controlled by cis-regulatory infraabdominal regions. The activation of these regions along the anteroposterior axis of the embryo determines where abdominal-A and Abdominal-B are transcribed. There is spatially restricted transcription of the infraabdominal regions (infraabdominal transcripts) that ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Development
دوره 101 1 شماره
صفحات -
تاریخ انتشار 1987